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First Author (Year) Design Methodological Concern 203 Han (2012) Open-label, crossover (clonazepam vs Ginkgo) No placebo control, lack of blinding Rejali (2004) Double-blind, placebo-controlled High attrition rate, data lacking relating to Ginkgo’s preparation, composition, or 207 standardization Morgenstern (2002) Double-blind, placebo-managed Patients pretreated with 10-day infusion of Ginkgo extract; allocation concealment unclear; very high 203 attrition Drew (2001) Double-blind, placebo-managed; whole research Exact diagnoses unsure; no doctor-patient contact; conducted via mail and phone existence and identification of sufferers unverifiable; no medical examination; no audiogram; questionable quality and reliability of data; difficult evaluation of 207,208 adverse events Juretzek (1998) (A) Open study; (B) double-blind, placebo-managed Not evaluated, research reported as an prolonged summary 206 solely Morgenstern (1997) Double-blind, placebo-managed None Holgers (1994) (A) Open research; (B) double-blind, placebo-managed, Patients pretreated with 2-week course of Ginkgo 203 crossover extract Meyer (1986a) Multicenter, double-blind, placebo-managed Allocation concealment unclear; attrition rate unclear; marked intergroup difference in severity of tinnitus; 203 no drop-out information given 206 Meyer (1986b) Multicenter, 3-armed Outcome measure was a specialist’s evaluation; no 203 placebo management 210 trazodone, resulting in increased sedation. 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